Melanotan 2 10mg
$65.00
- Free US shipping over $150
- HPLC-tested at 99%+ purity
- US-based fulfillment
Overview
Description
A melanocortin peptide researched for supporting tanning response and pigmentation pathways. Often chosen in appearance-focused research for deeper tone development and UV-response signaling.
Melanotan II is also commonly referenced for broader melanocortin signaling effects, making it a multi-purpose option in pigmentation and receptor-activity research models.
Scientific Overview
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (a-MSH) studied for activation of melanocortin receptors. Research explores its relationship to melanin production pathways and pigmentation response in experimental settings. Additional research interest includes melanocortin-linked appetite and behavioral signaling mechanisms.
Product Details
- Compound: Melanotan II
- Vial Size: 10mg
- Purity: ≥99%
- Form: Lyophilized powder
This product is intended strictly for laboratory research purposes only. It is not approved for human or veterinary use by the FDA or any other regulatory agency. Store in a cool, dry environment prior to reconstitution and handle using appropriate laboratory and aseptic techniques.
Frequently asked questions
Yes. Every batch of Melanotan 2 10mg undergoes independent third-party testing using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). The Certificate of Analysis is published and accessible from the product page.
Melanotan 2 10mg sold by MHS Longevity is verified to 99%+ purity, with the result documented in each batch's Certificate of Analysis. Anything below that threshold is rejected before release.
The Certificate of Analysis for Melanotan 2 10mg is available directly from the product page and on our Third-Party Test Results page. Each COA includes the batch identifier, test date, testing method, and verified purity percentage.
Melanotan 2 10mg ships from our US-based facility with standard or expedited options. Orders over $150 qualify for free standard US shipping. All orders are packaged discreetly with documented handling protocols.
No. Melanotan 2 10mg is supplied strictly for laboratory research purposes only. It is not approved by the FDA for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease.
MHS Longevity is a veteran-owned operation focused on pharmaceutical-grade research compounds. We source from vetted manufacturers, batch-test independently with HPLC and Mass Spectrometry, and publish every Certificate of Analysis. Pricing is transparent and the testing process is documented end-to-end.
Melanotan-2 has a molecular weight of approximately 1024.2 g/mol, with the empirical formula C50H69N15O9. This is documented on each batch's Certificate of Analysis alongside the Mass Spectrometry result confirming the cyclic structure and C-terminal amide.
Both share the same Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys] backbone — they descend from the same University of Arizona melanocortin-research program. The structural difference is at the C-terminus: Melanotan-2 has a C-terminal amide (-NH2), PT-141 has a C-terminal free acid (-OH). This one-atom difference shifts the receptor-affinity profile: Melanotan-2 retains substantial MC1R potency (driving the pigmentation-related research interest in the molecule), whereas PT-141 has a relatively reduced MC1R component and an emphasis on MC3R/MC4R effects. The two are related research tools that capture overlapping but distinct receptor pharmacology.
α-MSH is the 13-residue endogenous hormone (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) that activates the melanocortin receptors. Melanotan-2 is a cyclic 7-residue synthetic analogue designed to retain receptor-binding affinity while resisting the rapid enzymatic cleavage that limits native α-MSH's in-vivo activity. Both engage the same receptor family but with substantially different pharmacokinetic profiles in the published research.
Melanotan-2 is sent to an independent third-party laboratory for HPLC and Mass Spectrometry analysis before each batch is released. The lab's identifier and test date are published on the Certificate of Analysis for that batch, including the mass shifts confirming the lactam cyclization and the C-terminal amide.
Research & buying
The evidence behind Melanotan 2 10mg and the questions to ask any vendor before you order.
Research details — Melanotan 2 10mg
Melanotan-2 (sometimes written MT-II) is a synthetic cyclic heptapeptide developed at the University of Arizona's melanocortin-research program in the 1990s under Mac Hadley and Victor Hruby. It is a non-selective agonist at the melanocortin-receptor family — MC1R, MC3R, MC4R, and MC5R — and was the lead molecule from which the later analogue PT-141 (bremelanotide) was derived. Melanotan-2 has a substantial published preclinical literature on melanocortin-receptor pharmacology, with research interest spanning pigmentation biology, central-nervous-system effects mediated through MC3R/MC4R, and feeding-behavior research in animal models. This guide explains what Melanotan-2 is, the research context, and how its quality is independently verified.
What is Melanotan-2?
Melanotan-2 has the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, where Nle is norleucine, the cyclization is via a lactam bond between the Asp side chain and the Lys side chain, and the C-terminus is amidated. The molecular weight is approximately 1024.2 g/mol with the empirical formula C50H69N15O9. It is supplied as a lyophilized white powder for laboratory reconstitution.
Melanotan-2 is sold strictly for laboratory and research use. It is not approved by the FDA or any other regulatory body for human or veterinary use, and nothing in this guide constitutes guidance for human administration.
Research context
Published research on Melanotan-2 centers on the melanocortin-receptor family and the downstream consequences of broad-spectrum agonism across MC1R through MC5R. MC1R activation in melanocytes drives eumelanin synthesis — the mechanism underpinning the original research interest in skin pigmentation models. MC3R and MC4R activation in the central nervous system modulates feeding behavior and energy balance; MC4R-knockout phenotypes in animal models established that pathway's importance. The structural design — a cyclic heptapeptide with a non-natural Nle substitution and D-Phe stereochemistry — was a deliberate strategy to combine receptor binding affinity with metabolic stability. Researchers should evaluate the Hadley/Hruby publications and the broader melanocortin-receptor literature directly.
How Melanotan-2 quality is verified
Every batch of MHS Longevity Melanotan-2 is submitted to an independent third-party laboratory before release. The cyclic lactam, the non-standard Nle residue, the D-Phe stereochemistry, and the C-terminal amide are all verification targets:
- HPLC separates components and measures the Melanotan-2 peak as a percentage of total peak area. Linear (uncyclized) precursors elute at a distinguishable retention time. Stereochemical impurities — L-Phe in place of D-Phe — produce shifted retention times even though the mass is unchanged, so HPLC is the primary readout for that specific error. Anything below 99% is rejected.
- Mass Spectrometry confirms the molecular mass, the lactam cyclization (via -18 Da mass shift vs the linear form), and the C-terminal amide (via -1 Da vs free acid).
What a Melanotan-2 Certificate of Analysis shows
- Compound name and structural designation. Melanotan-2 / MT-II, with sequence notation including Nle, D-Phe, lactam cyclization, and C-terminal amide.
- Batch identifier. Unique ID linking certificate to vial.
- Test date. When the analysis was performed.
- Method. HPLC, MS, or both, with column and mobile-phase notes.
- Verified purity %. The HPLC result. We require 99%+.
- Structural modifications confirmed. MS mass shifts confirm both the lactam cyclization and the C-terminal amide.
- Lab and signatures. The independent lab performing the analysis.
Storage and handling (research lab context)
Lyophilized Melanotan-2 should be stored at -20°C or below for extended stability. Once reconstituted in bacteriostatic water, the solution is typically held at 2–8°C and used within the documented stability window. The Trp residue is light-sensitive — Melanotan-2 powder and reconstituted solutions should be protected from prolonged light exposure. The cyclic structure is otherwise more robust than equivalent linear sequences. Standard aseptic technique applies during reconstitution.
Where to buy Melanotan 2 10mg
The same eight questions apply whether you're buying Melanotan 2 10mgfrom us or anywhere else. Vendors who can't answer any of them are worth a closer look.
Vendor evaluation checklist
1. Is the Certificate of Analysis public and downloadable?
A vendor unwilling to publish HPLC/MS results for the batch you're buying has nothing to verify their purity claim against.
2. Which testing method was used — HPLC, Mass Spectrometry, or both?
HPLC measures purity. Mass Spectrometry confirms the molecule's identity. Reputable batches go through both.
3. What's the verified purity percentage on the published COA?
Industry research standard is 99%+. Below that, you're paying for a compound diluted with synthesis byproducts.
4. Where does the product ship from?
US-based fulfillment generally means shorter handling times, customs-free delivery, and clearer return remedies.
5. Is the price published at a single list rate, or hidden behind tier locks?
Opaque pricing is a yellow flag. Transparent vendors quote the same number to every customer.
6. What's the free-shipping threshold, if any?
Compare the all-in cost (product + shipping + handling) — not just the headline price.
7. How is the product stored prior to shipment?
Lyophilized peptides degrade with temperature swings. Vendors should disclose temperature-controlled storage.
8. Is there a documented damage-claim and return policy?
Discreet shipping carries handling risk. A clear, written policy protects you when something goes wrong.
MHS LongevityThis site - Price
- $65
- Purity
- 99%+
- Testing
- HPLC + MS
- COA public
- US-based
- Free shipping
- $150+
- Last checked
- May 13, 2026
| Vendor | Price | Listed purity | Testing method | COA public | US-based | Free shipping | Last checked |
|---|---|---|---|---|---|---|---|
MHS LongevityThis site | $65 | 99%+ | HPLC + MS | $150+ | May 13, 2026 |
Competitor data sourced from each vendor's public product page on the date shown. Listed purity reflects each vendor's own published claim; Certificate of Analysis availability is verified at the URL above. Data may have changed since last check.