Brain Health·Immunity·Longevity
MOTS-C 40mg
$220.00
- Free US shipping over $150
- HPLC-tested at 99%+ purity
- US-based fulfillment
Used in Weight Loss Protocol and Longevity Protocol.
Overview
Description
A mitochondrial-derived peptide researched for improving how cells utilize fat and glucose for fuel. Often selected for metabolic flexibility and endurance-focused goals.
MOTS-C is commonly explored in research for supporting insulin sensitivity and efficient energy output, making it a strong fit for performance, longevity, and metabolic-optimization protocols.
Scientific Overview
MOTS-C is a mitochondrial-encoded peptide studied for its role in cellular energy homeostasis. Research suggests it may influence pathways involved in glucose and lipid utilization, including AMPK-related signaling, which is closely tied to metabolic efficiency and mitochondrial performance in experimental models.
Product Details
- Compound: MOTS-C (mitochondrial-derived peptide)
- Vial Size: 40mg
- Purity: ≥99%
- Form: Lyophilized powder
This product is intended strictly for laboratory research purposes only. It is not approved for human or veterinary use by the FDA or any other regulatory agency. Store in a cool, dry environment prior to reconstitution and handle using appropriate laboratory and aseptic techniques.
Frequently asked questions
Yes. Every batch of MOTS-C 40mg undergoes independent third-party testing using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). The Certificate of Analysis is published and accessible from the product page.
MOTS-C 40mg sold by MHS Longevity is verified to 99%+ purity, with the result documented in each batch's Certificate of Analysis. Anything below that threshold is rejected before release.
The Certificate of Analysis for MOTS-C 40mg is available directly from the product page and on our Third-Party Test Results page. Each COA includes the batch identifier, test date, testing method, and verified purity percentage.
MOTS-C 40mg ships from our US-based facility with standard or expedited options. Orders over $150 qualify for free standard US shipping. All orders are packaged discreetly with documented handling protocols.
No. MOTS-C 40mg is supplied strictly for laboratory research purposes only. It is not approved by the FDA for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease.
MHS Longevity is a veteran-owned operation focused on pharmaceutical-grade research compounds. We source from vetted manufacturers, batch-test independently with HPLC and Mass Spectrometry, and publish every Certificate of Analysis. Pricing is transparent and the testing process is documented end-to-end.
MOTS-C is encoded within mitochondrial DNA rather than nuclear DNA. It sits in a class called "mitochondrial-derived peptides" — a relatively recently characterized group of short bioactive sequences from the mitochondrial genome. Most peptides studied in research come from nuclear-encoded genes; MOTS-C is one of the most-cited exceptions.
MOTS-C's reported mechanism centers on the AMPK metabolic-sensing pathway and on regulation of glucose-handling genes. This is different from, for example, the redox-coenzyme role of NAD+ or the telomere-related research focus on Epitalon. Researchers comparing MOTS-C to other longevity-research compounds should review the AMPK-pathway literature directly.
MOTS-C is sent to an independent third-party laboratory for HPLC and Mass Spectrometry analysis before each batch is released. The lab's identifier and test date are published on the Certificate of Analysis for that batch.
MOTS-C is a 16-amino-acid peptide, longer than many compounds we stock, which affects synthesis economics. The 40mg vial size is set to match typical research-lab protocol volumes for this compound while keeping the per-vial cost reasonable. Each batch is independently tested regardless of vial size.
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Research & buying
The evidence behind MOTS-C 40mg and the questions to ask any vendor before you order.
Research details — MOTS-C 40mg
MOTS-C is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. It was first reported in 2015 by Pinchas Cohen's laboratory at USC, and it sits in a class of so-called "mitochondrial-derived peptides" — short bioactive sequences encoded by the mitochondrial genome rather than the nuclear genome. This guide explains what MOTS-C is, the research context, and how each batch is verified before release.
What is MOTS-C?
MOTS-C ("Mitochondrial Open Reading Frame of the 12S rRNA-c") has the sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg. The molecular weight is approximately 2174.6 g/mol with empirical formula C107H156N32O22S2. It is supplied as a lyophilized white-to-off-white powder for laboratory reconstitution.
MOTS-C is sold strictly for laboratory and research use. It is not approved by the FDA or any other regulatory body for human or veterinary use, and nothing in this guide constitutes guidance for human administration.
Research context
Published research on MOTS-C centers on metabolic regulation and the AMPK signaling pathway in skeletal muscle, adipose tissue, and liver. Animal-model work has examined effects on glucose homeostasis, insulin sensitivity, and exercise-induced gene expression. The compound is also referenced in aging-biology literature — circulating MOTS-C levels appear to decline with age in some human cohort studies. Researchers should evaluate primary sources, including Lee et al. 2015 and subsequent follow-on work, directly.
How MOTS-C quality is verified
Every batch of MHS Longevity MOTS-C is submitted to an independent third-party laboratory before release:
- HPLC separates components and measures the MOTS-C peak as a percentage of total peak area. Anything below 99% is rejected.
- Mass Spectrometry confirms the molecule's mass matches the published 16-amino-acid MOTS-C sequence. For a peptide of this length, MS-confirmed identity is important — it rules out truncated or deletion-variant impurities.
What a MOTS-C Certificate of Analysis shows
- Compound name and structural designation. MOTS-C, with the full 16-amino-acid sequence and molecular formula.
- Batch identifier. The unique ID linking certificate to vial.
- Test date. When the analysis was performed.
- Method. HPLC, MS, or both, with column and mobile-phase notes.
- Verified purity %. The HPLC result. We require 99%+.
- Lab and signatures. The independent lab performing the analysis.
Storage and handling (research lab context)
Lyophilized MOTS-C should be stored at -20°C or below for extended stability. Once reconstituted in bacteriostatic water, the solution is typically held at 2–8°C. Repeated freeze–thaw cycles should be avoided, and the powder should be protected from light and moisture. Standard aseptic technique applies.
Further reading
Where to buy MOTS-C 40mg
The same eight questions apply whether you're buying MOTS-C 40mgfrom us or anywhere else. Vendors who can't answer any of them are worth a closer look.
Vendor evaluation checklist
1. Is the Certificate of Analysis public and downloadable?
A vendor unwilling to publish HPLC/MS results for the batch you're buying has nothing to verify their purity claim against.
2. Which testing method was used — HPLC, Mass Spectrometry, or both?
HPLC measures purity. Mass Spectrometry confirms the molecule's identity. Reputable batches go through both.
3. What's the verified purity percentage on the published COA?
Industry research standard is 99%+. Below that, you're paying for a compound diluted with synthesis byproducts.
4. Where does the product ship from?
US-based fulfillment generally means shorter handling times, customs-free delivery, and clearer return remedies.
5. Is the price published at a single list rate, or hidden behind tier locks?
Opaque pricing is a yellow flag. Transparent vendors quote the same number to every customer.
6. What's the free-shipping threshold, if any?
Compare the all-in cost (product + shipping + handling) — not just the headline price.
7. How is the product stored prior to shipment?
Lyophilized peptides degrade with temperature swings. Vendors should disclose temperature-controlled storage.
8. Is there a documented damage-claim and return policy?
Discreet shipping carries handling risk. A clear, written policy protects you when something goes wrong.
MHS LongevityThis site - Price
- $220
- Purity
- 99%+
- Testing
- HPLC + MS
- COA public
- US-based
- Free shipping
- $150+
- Last checked
- May 13, 2026
| Vendor | Price | Listed purity | Testing method | COA public | US-based | Free shipping | Last checked |
|---|---|---|---|---|---|---|---|
MHS LongevityThis site | $220 | 99%+ | HPLC + MS | $150+ | May 13, 2026 |
Competitor data sourced from each vendor's public product page on the date shown. Listed purity reflects each vendor's own published claim; Certificate of Analysis availability is verified at the URL above. Data may have changed since last check.