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Brain Health·Longevity

NAD+ 500mg

$110.00

1
  • Free US shipping over $150
  • HPLC-tested at 99%+ purity
  • US-based fulfillment
Certificate of Analysis document for NAD+ 500mg

Used in Longevity Protocol.

Overview

Description

A foundational longevity molecule researched for supporting cellular energy production, mitochondrial performance, and natural repair processes.

NAD+ is commonly associated in research with mental clarity, steady energy, and healthy aging pathways— making it a popular core option in longevity-focused protocols.

Scientific Overview

Nicotinamide Adenine Dinucleotide (NAD+) is a naturally occurring coenzyme found in all living cells. It plays a central role in redox reactions that drive cellular energy metabolism and mitochondrial function. NAD+ also serves as a key substrate for enzymes involved in DNA repair and cellular signaling, which is why it remains a major focus in aging and metabolic research.

Product Details

  • Compound: Nicotinamide Adenine Dinucleotide (NAD+)
  • Vial Size: 500mg
  • Purity: ≥99%
  • Form: Lyophilized powder

This product is intended strictly for laboratory research purposes only. It is not approved for human or veterinary use by the FDA or any other regulatory agency. Store in a cool, dry environment prior to reconstitution and handle using appropriate laboratory and aseptic techniques.

Frequently asked questions

Yes. Every batch of NAD+ 500mg undergoes independent third-party testing using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). The Certificate of Analysis is published and accessible from the product page.

NAD+ 500mg sold by MHS Longevity is verified to 99%+ purity, with the result documented in each batch's Certificate of Analysis. Anything below that threshold is rejected before release.

The Certificate of Analysis for NAD+ 500mg is available directly from the product page and on our Third-Party Test Results page. Each COA includes the batch identifier, test date, testing method, and verified purity percentage.

NAD+ 500mg ships from our US-based facility with standard or expedited options. Orders over $150 qualify for free standard US shipping. All orders are packaged discreetly with documented handling protocols.

No. NAD+ 500mg is supplied strictly for laboratory research purposes only. It is not approved by the FDA for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease.

MHS Longevity is a veteran-owned operation focused on pharmaceutical-grade research compounds. We source from vetted manufacturers, batch-test independently with HPLC and Mass Spectrometry, and publish every Certificate of Analysis. Pricing is transparent and the testing process is documented end-to-end.

No. NAD+ is a coenzyme — a dinucleotide built from nicotinamide and adenine ribonucleotides. It does not contain amino acids and is not synthesized by peptide-bond chemistry. The same independent HPLC and Mass Spectrometry methods used for peptides are used to verify NAD+ purity and identity.

NMN (nicotinamide mononucleotide) is a biosynthetic precursor to NAD+ in the salvage pathway. They are related but chemically distinct molecules with different molecular weights and different HPLC retention times. A high-quality NAD+ COA will distinguish the two and show NMN-related species, if any, as below the 99%+ threshold.

NAD+ is sent to an independent third-party laboratory for HPLC and Mass Spectrometry analysis before each batch is released. The lab's identifier and test date are published on the Certificate of Analysis for that batch.

NAD+ is hygroscopic, light-sensitive, and readily interconverts with its reduced form NADH under aerobic conditions. Most lyophilized peptides are stable for extended periods at -20°C with routine handling; NAD+ benefits from stricter aliquoting, refrigerated handling once reconstituted, and minimal exposure to ambient air and light.

Research & buying

The evidence behind NAD+ 500mg and the questions to ask any vendor before you order.

Research details — NAD+ 500mg

NAD+ (nicotinamide adenine dinucleotide) is not a peptide — it is a coenzyme present in every living cell, central to redox biochemistry and a substrate for several classes of enzyme. We stock it because the longevity-research community frequently uses it alongside peptide compounds, and the same testing-and-COA discipline we apply to peptides applies to coenzymes too. This guide explains what NAD+ is, the research context, and how its quality is verified.

What is NAD+?

NAD+ is a dinucleotide built from two nucleotides joined through their phosphate groups: one carrying the nicotinamide base, the other carrying the adenine base. The molecular formula is C21H27N7O14P2 with a molecular weight of approximately 663.4 g/mol. It is supplied as a lyophilized off-white powder for laboratory reconstitution.

NAD+ is sold strictly for laboratory and research use. It is not approved by the FDA or any other regulatory body for human or veterinary use, and nothing in this guide constitutes guidance for human administration.

Research context

NAD+ has been studied extensively for its role in redox reactions, mitochondrial energy production, and as a substrate for enzyme families including the sirtuins (SIRT1–SIRT7) and the PARPs (poly-ADP-ribose polymerases), both of which consume NAD+ as part of their catalytic activity. NAD+ pool dynamics are an active topic in the aging-biology literature, with published work examining tissue-level NAD+ decline in older mammals and the consequences for metabolic and DNA-repair pathways.

How NAD+ quality is verified

Although NAD+ is not a peptide, the analytical methods used to verify its purity and identity are the same in principle as those used for peptides. Every batch of MHS Longevity NAD+ is submitted to an independent third-party laboratory before release:

  • HPLC separates components of the sample and measures the NAD+ peak as a percentage of total peak area. The dominant impurities to watch for in NAD+ samples are NADH (the reduced form) and nicotinamide mononucleotide (NMN, a precursor); both have distinct retention times. Anything below 99% NAD+ is rejected.
  • Mass Spectrometry confirms the molecule's mass matches the published NAD+ structure. Because NAD+ is hygroscopic and air-sensitive, MS-confirmed identity at the batch level is particularly informative — it rules out partial conversion to NADH or degradation products that share similar retention.

What an NAD+ Certificate of Analysis shows

  1. Compound name and structural designation. NAD+ (nicotinamide adenine dinucleotide), with molecular formula and molecular weight.
  2. Batch identifier. The unique ID linking certificate to vial.
  3. Test date. When the analysis was performed. NAD+ is more sensitive than many peptides to storage conditions, so recent dates matter.
  4. Method. HPLC, MS, or both, with column and mobile-phase notes.
  5. Verified purity %. The HPLC result. We require 99%+ NAD+ relative to NADH/NMN and other related species.
  6. Lab and signatures. The independent lab performing the analysis.

Storage and handling (research lab context)

NAD+ is more sensitive than most lyophilized peptides. Lyophilized NAD+ should be stored at -20°C or below, protected from light and moisture. Once reconstituted, the solution should be kept refrigerated and used quickly — NAD+ readily oxidizes and equilibrates with NADH under aerobic conditions, which is why MS confirmation at the batch level is informative. Avoid repeated freeze–thaw cycles and aliquot for single-use where possible.

Further reading

Where to buy NAD+ 500mg

The same eight questions apply whether you're buying NAD+ 500mgfrom us or anywhere else. Vendors who can't answer any of them are worth a closer look.

Vendor evaluation checklist

  1. 1. Is the Certificate of Analysis public and downloadable?

    A vendor unwilling to publish HPLC/MS results for the batch you're buying has nothing to verify their purity claim against.

  2. 2. Which testing method was used — HPLC, Mass Spectrometry, or both?

    HPLC measures purity. Mass Spectrometry confirms the molecule's identity. Reputable batches go through both.

  3. 3. What's the verified purity percentage on the published COA?

    Industry research standard is 99%+. Below that, you're paying for a compound diluted with synthesis byproducts.

  4. 4. Where does the product ship from?

    US-based fulfillment generally means shorter handling times, customs-free delivery, and clearer return remedies.

  5. 5. Is the price published at a single list rate, or hidden behind tier locks?

    Opaque pricing is a yellow flag. Transparent vendors quote the same number to every customer.

  6. 6. What's the free-shipping threshold, if any?

    Compare the all-in cost (product + shipping + handling) — not just the headline price.

  7. 7. How is the product stored prior to shipment?

    Lyophilized peptides degrade with temperature swings. Vendors should disclose temperature-controlled storage.

  8. 8. Is there a documented damage-claim and return policy?

    Discreet shipping carries handling risk. A clear, written policy protects you when something goes wrong.

NAD+ 500mg — vendor comparison
  • MHS LongevityThis site
    Price
    $110
    Purity
    99%+
    Testing
    HPLC + MS
    COA public
    US-based
    Free shipping
    $150+
    Last checked
    May 13, 2026

Competitor data sourced from each vendor's public product page on the date shown. Listed purity reflects each vendor's own published claim; Certificate of Analysis availability is verified at the URL above. Data may have changed since last check.