Biochemicals
Thymosin Alpha-1 5mg
$95.00
- Free US shipping over $150
- HPLC-tested at 99%+ purity
- US-based fulfillment
Used in Longevity Protocol.
Overview
Description
An immune-support peptide researched for immune signaling balance and resilience. Often selected during periods of high stress, immune suppression, or when consistent immune readiness is the priority.
Thymosin Alpha-1 is commonly explored in research around T-cell signaling and immune modulation, making it a foundational option for immune-focused protocols.
Scientific Overview
Thymosin Alpha-1 is a synthetic peptide originally derived from thymosin fraction 5 and studied for immunomodulatory properties. Research includes effects on T-cell differentiation, cytokine regulation, and innate immune signaling pathways in experimental models. It remains of interest across immune balance, antiviral-response mechanisms, and immunotherapy-related research settings.
Product Details
- Compound: Thymosin Alpha-1
- Vial Size: 5mg
- Purity: ≥99%
- Form: Lyophilized powder
This product is intended strictly for laboratory research purposes only. It is not approved for human or veterinary use by the FDA or any other regulatory agency. Store in a cool, dry environment prior to reconstitution and handle using appropriate laboratory and aseptic techniques.
Frequently asked questions
Yes. Every batch of Thymosin Alpha-1 5mg undergoes independent third-party testing using High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). The Certificate of Analysis is published and accessible from the product page.
Thymosin Alpha-1 5mg sold by MHS Longevity is verified to 99%+ purity, with the result documented in each batch's Certificate of Analysis. Anything below that threshold is rejected before release.
The Certificate of Analysis for Thymosin Alpha-1 5mg is available directly from the product page and on our Third-Party Test Results page. Each COA includes the batch identifier, test date, testing method, and verified purity percentage.
Thymosin Alpha-1 5mg ships from our US-based facility with standard or expedited options. Orders over $150 qualify for free standard US shipping. All orders are packaged discreetly with documented handling protocols.
No. Thymosin Alpha-1 5mg is supplied strictly for laboratory research purposes only. It is not approved by the FDA for human or veterinary use, and it is not intended to diagnose, treat, cure, or prevent any disease.
MHS Longevity is a veteran-owned operation focused on pharmaceutical-grade research compounds. We source from vetted manufacturers, batch-test independently with HPLC and Mass Spectrometry, and publish every Certificate of Analysis. Pricing is transparent and the testing process is documented end-to-end.
Thymosin Alpha-1 has a molecular weight of approximately 3108 g/mol. This is documented on each batch's Certificate of Analysis alongside the Mass Spectrometry result confirming the N-terminal acetylation.
Thymosin Alpha-1 is one of several biologically active peptides originally isolated from a fractionated thymus extract called 'thymosin fraction 5.' Each fraction-5 peptide is a distinct molecule with its own biological role — Tα1 specifically is the 28-residue acetylated peptide described in this guide. Other thymosin family members (Thymosin Beta-4, for example) are entirely different proteins with different functions; the shared 'thymosin' name reflects their common tissue of origin, not structural similarity.
Yes. Thymalfasin is the International Nonproprietary Name (INN) for the synthetic form of Thymosin Alpha-1. The two terms refer to the same 28-amino-acid acetylated peptide. Pharmaceutical preparations under various brand names use this INN; research-grade lyophilized peptide supplied here is the same active species but is not formulated as a pharmaceutical product and is not approved for human use.
Thymosin Alpha-1 is sent to an independent third-party laboratory for HPLC and Mass Spectrometry analysis before each batch is released. The lab's identifier and test date are published on the Certificate of Analysis for that batch, including explicit confirmation of the N-terminal acetylation via the +42 Da mass shift.
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Research & buying
The evidence behind Thymosin Alpha-1 5mg and the questions to ask any vendor before you order.
Research details — Thymosin Alpha-1 5mg
Thymosin Alpha-1 (often abbreviated Tα1 or TA-1) is a 28-amino-acid peptide originally isolated from bovine thymus extracts in the late 1970s by Allan Goldstein's research group at George Washington University. It is one of the longest-studied research peptides in immunomodulation work and remains a reference compound for studying TLR-dependent and TLR-independent innate-immune signaling. This guide explains what Thymosin Alpha-1 is, the research context, and how its quality is independently verified before release.
What is Thymosin Alpha-1?
Thymosin Alpha-1 has the sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn — 28 residues with an N-terminal acetyl modification. The molecular weight is approximately 3108 g/mol. The N-terminal acetylation is a post-translational modification of the native endogenous molecule and is reproduced in synthetic preparations because removing it changes receptor binding. It is supplied as a lyophilized white powder for laboratory reconstitution.
Thymosin Alpha-1 is sold strictly for laboratory and research use. It is not approved by the FDA for human or veterinary use in the research-grade form supplied here. Pharmaceutical preparations of thymalfasin (the international name for thymosin alpha-1) are approved in numerous countries outside the United States for specific clinical indications; those are entirely separate products produced through different regulatory channels.
Research context
Published research on Thymosin Alpha-1 spans more than four decades. The molecule was first studied in the context of T-cell maturation and thymus biology, then progressively characterized as a modulator of innate-immune signaling. Current research literature describes binding to Toll-like receptors (particularly TLR9 in some contexts and TLR2 in others) and downstream effects on dendritic-cell maturation, NK-cell activity, and the balance between Th1 and Th2 cytokine profiles. Researchers should evaluate the primary literature directly — there is a large body of clinical work outside the United States that informs the molecule's pharmacology.
How Thymosin Alpha-1 quality is verified
Every batch of MHS Longevity Thymosin Alpha-1 5mg is submitted to an independent third-party laboratory before release. The N-terminal acetylation is a specific verification target alongside standard purity testing:
- HPLC separates components by chemistry. The acetylated form elutes at a slightly different retention time from the non-acetylated form (since acetylation changes the molecule's hydrophobicity). Both peaks would be visible if acetylation is incomplete; anything below 99% acetylated target is rejected.
- Mass Spectrometry confirms the acetylation directly via the mass shift (+42 Da vs the non-acetylated form). This is the verification step that catches incompletely-acetylated synthesis products, which HPLC alone might not resolve if the retention times are close.
What a Thymosin Alpha-1 Certificate of Analysis shows
- Compound name and structural designation. Thymosin Alpha-1 / Tα1 / thymalfasin, with full 28-residue sequence and N-terminal acetylation notation.
- Batch identifier. Unique ID linking certificate to vial.
- Test date. When the analysis was performed.
- Method. HPLC, MS, or both, with column and mobile-phase notes.
- Verified purity %. The HPLC result. We require 99%+.
- N-terminal acetylation confirmation. MS mass shift (+42 Da vs non-acetylated form) confirms the modification.
- Lab and signatures. The independent lab performing the analysis.
Storage and handling (research lab context)
Lyophilized Thymosin Alpha-1 should be stored at -20°C or below for extended stability. Once reconstituted in bacteriostatic water, the solution is typically held at 2–8°C and used within the documented stability window. The 28-residue length and lack of cysteine residues make this molecule comparatively robust among research peptides — no disulfide concerns, no obvious oxidation hotspots — but standard aseptic technique and protection from repeated freeze–thaw cycles still apply.
Where to buy Thymosin Alpha-1 5mg
The same eight questions apply whether you're buying Thymosin Alpha-1 5mgfrom us or anywhere else. Vendors who can't answer any of them are worth a closer look.
Vendor evaluation checklist
1. Is the Certificate of Analysis public and downloadable?
A vendor unwilling to publish HPLC/MS results for the batch you're buying has nothing to verify their purity claim against.
2. Which testing method was used — HPLC, Mass Spectrometry, or both?
HPLC measures purity. Mass Spectrometry confirms the molecule's identity. Reputable batches go through both.
3. What's the verified purity percentage on the published COA?
Industry research standard is 99%+. Below that, you're paying for a compound diluted with synthesis byproducts.
4. Where does the product ship from?
US-based fulfillment generally means shorter handling times, customs-free delivery, and clearer return remedies.
5. Is the price published at a single list rate, or hidden behind tier locks?
Opaque pricing is a yellow flag. Transparent vendors quote the same number to every customer.
6. What's the free-shipping threshold, if any?
Compare the all-in cost (product + shipping + handling) — not just the headline price.
7. How is the product stored prior to shipment?
Lyophilized peptides degrade with temperature swings. Vendors should disclose temperature-controlled storage.
8. Is there a documented damage-claim and return policy?
Discreet shipping carries handling risk. A clear, written policy protects you when something goes wrong.
MHS LongevityThis site - Price
- $95
- Purity
- 99%+
- Testing
- HPLC + MS
- COA public
- US-based
- Free shipping
- $150+
- Last checked
- May 13, 2026
| Vendor | Price | Listed purity | Testing method | COA public | US-based | Free shipping | Last checked |
|---|---|---|---|---|---|---|---|
MHS LongevityThis site | $95 | 99%+ | HPLC + MS | $150+ | May 13, 2026 |
Competitor data sourced from each vendor's public product page on the date shown. Listed purity reflects each vendor's own published claim; Certificate of Analysis availability is verified at the URL above. Data may have changed since last check.